Development of malaria vaccines

Partner Institution(s): 
National Institute for Medical Research, Tanzania
Kilimanjaro Christian Medical Centre/Kilimanjaro Christian Medical University, Tanzania
Start Date: 
January 1, 2013
End Date: 
December 31, 2017
Project Code: 
Total grant: 
DKK 10,119,987
Contact : 
Thor Grundtvig Theander

Malaria is responsible for an overwhelming disease burden and
deployment of effective malaria vaccines would lead to major health
gains, especially among most vulnerable groups: young children and
pregnant women in rural areas. Tanzania and Denmark are in the
international forefront of malaria vaccine research. Tanzania has
developed the human resources and technical infrastructure to conduct
clinical malaria vaccine trials in compliance with the rules for Good
Clinical Practices. Research groups in Denmark are internationally
recognised as leading the attempts to develop vaccines to protect women
against malaria in pregnancy and in defining antigens for vaccines to
protect children against severe malaria. The proposal is based on built
capacity, a malaria research needs-assessment and the aspiration of
linking to the Building Stronger Universities programme activities and
filling institutional needs at the Tanzanian institutions. We propose to
lay the scientific foundation for multivalent malaria vaccines targeting
two essential host/parasite interactions (the parasite invasion of red blood
cells (RBC) and the binding of infected RBC to the vascular lining) and
delivering the vaccines on virus particles. The potential benefit of this
approach is that such vaccines would induce solid immunological
memory and also provide protection against a virus such as human
papilloma virus causing cervical cancer, which, as malaria, constitutes a
major health problem in Africa.


Midterm report 2016:
Numerous insights has been made which will forward development and deployment of malaria vaccines.

This page was last modified on 21 August 2017

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