University of Copenhagen (UCPH)/Rigshospitalet, Denmark

Malaria vaccine research and capacity building in Ghana

The applicants have previously collaborated successfully on malaria vaccine development, and have characterised a field site area prioritised by Ghana Health Services. This project builds on these strengths, and will focus on research and capacity b ... Project completion report: The type of malaria that dominates in Africa is also the most serious type of the disease. It continues to cost almost half a million lives a year there, mainly among young children. Progress over the last decade to ...

Development of malaria vaccines

Malaria is responsible for an overwhelming disease burden and deployment of effective malaria vaccines would lead to major health gains, especially among most vulnerable groups: young children and pregnant women in rural areas. Tanzania and Denmark ... Project completion report: The main aim and long term aim of this project was to develop new vaccines to malaria. The work proceeded along the normal rute for new medicinal products. The work was divided into a Discovery phase (discovery of n ...

Neonatal Hospital Mortality in South Vietnam

Overall aim: To examine newborn hospital mortality in South Vietnam in order to design intervention studies to be conducted in the next project phase. The studies are conducted in a tertiary specialized hospital and 3 referring secondary general pro ... Project Completion Report: In spite of the magnitude, knowledge about newbom mortality is very limited in resource poor settings like Vietnam. We explored newborn morbidity and mortality in hospital (general and specialized pediatric care) an ...

Safety and efficacy of antimalarial therapy in children with HIV and sickle cell disease:data to aid policy formulation in Ghana

HIV infection (HIV) and sickle cell disease (SCD) are widespread chronic diseases in Africa, and there is major risk of co-infection of these diseases with malaria, particularly in children. Both HIV and SCD may aggravate malaria, and anti-malarial ... Project Completion Report: There is little information on the contribution of malaria to the morbidity experienced by children with HIV infection or sickle cell disease (SCD), two major diseases of public health importance in malaria-endemic ...

Assessment of the efficacy of a VAR2CSA based vaccine to prevent malaria in pregnant women

Malaria is the cause of severe maternal anaemia and is responsible for about one third of preventable low birth weight babies. It contributes to the deaths of an estimated 10,000 pregnant women and up to 200,000 infants each year in Afica alone. At ... Annual Report 2012: Protection to the clinical symptoms of placental malaria is acquired along parity suggesting that it is feasible to make a vaccine against placental malaria. In this project we have produced a single domain of the parasite ...

Development of PfEMP1 based malaria vaccines

PfEMP1 are a class of parasite proteins expressed on the surface of Plamosium falciparum-infected erythrocytes, where they function as adhesion receptors interacting with a range of host tissue ligands. Tissue adhesion of infected erythrocytes is a ... Project Completion Report: During this project we have: developed the first vaccine to protect women for pregnancy associated malaria planned to undergo clinical testing with the next years, defined the parasite proteins which precipitates se ...

Development of high throughput immunoassays for analysing artemisinin & derivatives

During the project period specific monoclonal antibodies (MAbs) have been raised against artesunate (ARS), dihydroartemisinin (DHA), chloroquine (CQ) and amodiaquine (AQ). By using these antibodies, highly sensitive and specific enzyme-linked immuno ...